Ca2+tapulting HSCs into action
نویسندگان
چکیده
منابع مشابه
Do HSCs divide asymmetrically?
Hematopoiesis is maintained by stem cells with the ability to both self-renew and to give rise to differentiated progeny. A proper balance between these fates is essential to prevent hematopoietic failure or uncontrolled stem cell expansion. So how do HSCs undergo self-renewal? In theory, this can occur in 2 ways; either through symmetrical cell division (SCD) where 2 new stem cells are formed,...
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Haematopoiesis in adult animals is maintained by haematopoietic stem cells (HSCs), which self-renew and can give rise to all blood cell lineages. The AGM region is an important intra-embryonic site of HSC development and a wealth of evidence indicates that HSCs emerge from the endothelium of the embryonic dorsal aorta and extra-embryonic large arteries. This, however, is a stepwise process that...
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During mouse development, definitive hematopoietic stem cells (dHSCs) emerge by late E10.5 to E11 in several hematopoietic sites. Of them, the aorta-gonad-mesonephros (AGM) region drew particular attention owing to its capacity to autonomously initiate and expand dHSCs in culture, indicating its key role in HSC development. The dorsal aorta contains characteristic hematopoietic clusters and is ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2018
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.20181097